Risk factors for portal venous thrombosis after operation of portal hypertension

Objective To investigate the risk factors for portal vein thrombosis(PVT) after surgery in patients with cirrhosis and portal hypertension.Methods Patients underwent operation for portal hypersplenism and variceal bleeding in Ruijn Hospital between Jan 2008 and Jul 2010 were retrospectively analyzed.All the patients with postoperative PVT or without were divided into two groups.We analyzed the factors to relate with PVT.Results PVT developed in 40(43.47%) of 92 patients after surgery.Portal vein diameter and splenic vein diameter were both independent risk factors for PVT(P 0.01).However,sex,age,aetiology,Child-Pugh classification,serum total billirubin,serum albumin,prothrombin time,portal venous flow,portal venous velocity,type of operation,free portal pressure,platelet count,D-dimer were not independent risk factors.Postoperative PVT tended to occur when portal vein diameter over 11.65 mm or splenic vein diameter over 9.5 mm.Conclusions Portal vein diameter and splenic vein diameter are independent risk factors for PVT after surgery in patients with cirrhosis and portal hypertension.