Clinical analysis on cervical intraepithelial neoplasia treatd by loop electrosurgical excision procedure

Objective:To analyse the clinical effect of multiple punch biopsy under colposcopy combined with loop electrosurgical excision procedure (LEEP) on cervical intraepithelial neoplasia Ⅱ~Ⅲ.Methods:A retrospective analysis was performed on 78 CIN Ⅱ~Ⅲ cases after multiple punch biopsy under colposcopy combined with LEEP from January 2005 to June 2007.The pathological results and recurrence of 78 cases by multiple punch biopsy under colposcopy and LEEP were compared by before-after study.Results:The pathologic diagnostic accordance rate of multiple punch biopsy under colposcopy and LEEP was 70.51% (55/78),the proportions of upgrading and downgrading were 8.97% (7/78) and 20.51% (16/78),respectively,there was significant difference in pathologic diagnostic rate between multiple punch biopsy under colposcopy and LEEP (P0.05).The cure rate was 93.42% (71/76),and the recurrence rate was 2.63% (2/76).Conclusion:LEEP is a safe and effective method to treat CIN Ⅱ~Ⅲ,which has a high cure rate and less postoperative complications.It is very significant to apply multiple punch biopsy under colposcopy combined with LEEP in the diagnosis of CIN Ⅱ~Ⅲ and early cervical cancer.