ScholarLens Back to search
2004•Chongqing Yike Daxue xuebaoRequires access

Effects of nimesulide on proliferation and apoptosis of human gastric carcinoma cells SGC-7901

Min Qiao

Open publisher page 0 citations

Abstract

Objective:To study the effects of nimesulide on proliferation and apoptosis of human gastric carcinoma cells SGC-7901 in vitro,and provide an experimental basis for clinical application.Methods:Proliferation of human gastric carcinoma cells SGC-7901 was assessed by MTT,and apoptosis was detected by transmission electron microscope and flow cytometry.Results:Proliferation of SGC-7901 was inhibited significantly by nimesulide(range from 12.5 to 800μmol/L) in a dosage-dependant manner ( P 0.05).Under transmission electron microscope and fluorescent microscope,some SGC-7901 cells undergo a typical apoptosis after 4 days incubation with nimesulide.There is an apoptosis peak.Conclusion:Nimesulide can suppress proliferation of SGC-7901 cells,which may be related to the mechanism of inducing cell apoptosis and preventing development of cell cycle.

About this research paper

What this paper is about

Objective:To study the effects of nimesulide on proliferation and apoptosis of human gastric carcinoma cells SGC-7901 in vitro,and provide an experimental basis for clinical application.Methods:Proliferation of human gastric carcinoma cells SGC-7901 was assessed by MTT,and apoptosis was detected by transmission electron microscope and flow cytometry.Results:Proliferation of SGC-7901 was inhibited significantly by nimesulide(range from 12.5 to 800μmol/L) in a dosage-dependant manner ( P 0.05).Under transmission electron microscope and fluorescent microscope,some SGC-7901 cells undergo a typical apoptosis after 4 days incubation with nimesulide.There is an apoptosis peak.Conclusion:Nimesulide can suppress proliferation of SGC-7901 cells,which may be related to the mechanism of inducing cell apoptosis and preventing development of cell cycle.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To study the effects of nimesulide on proliferation and apoptosis of human gastric carcinoma cells SGC-7901 in vitro,and provide an experimental basis for clinical application.Methods:Proliferation of human gastric carcinoma cells SGC-7901 was assessed by MTT,and apoptosis was detected by transmission electron microscope and flow cytometry.Results:Proliferation of SGC-7901 was inhibited significantly by nimesulide(range from 12.5 to 800μmol/L) in a dosage-dependant manner ( P 0.05).Under transmission electron microscope and fluorescent microscope,some SGC-7901 cells undergo a typical apoptosis after 4 days incubation with nimesulide.There is an apoptosis peak.Conclusion:Nimesulide can suppress proliferation of SGC-7901 cells,which may be related to the mechanism of inducing cell apoptosis and preventing development of cell cycle.

Key concepts: Nimesulide, Apoptosis, Flow cytometry, Cell growth, Cell cycle, In vitro, MTT assay, Cell

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of nimesulide on proliferation and apoptosis of human gastric carcinoma cells SGC-7901 — Research Paper | ScholarLens