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EXPERIMENTAL STUDY ON APOPTOSIS OF HUMAN GASTRIC CARCINOMA CELLS INDUCED BY FUZHENGXIAOZHENG PRESCRIPTION

Ren Ye

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Abstract

Objective: To investigate the apoptosis of SGC-7901 cell induced by fuzhengxiaozheng prescription, study its antitumor mechanism in vitro. Methods: The proliferation of SGC-7901 cells was measured by MTT colorimetric assay, the apoptosis cell was analysised by flow cytometry. Results: Fuzhengxiaozheng prescription could inhibit the proliferation of SGC-7901 cells in dose-dependent manner and in time-dependent manner from 0h to 72h. The cells cultured with fuzhengxiaozheng prescription showed an apoptotic peak which was lower than that of diploid before G1 phase. The typical apoptosis morphology and hypodiploid changes of SGC-7901 were examined by electron microscopy. Conclusion: Fuzhengxiaozheng prescription can inhibit the growth of SGC-7901 in vitro,inhibiting its proliferation and inducing its apoptosis maybe one of its antitumor mechanism. KMBWM

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What this paper is about

Objective: To investigate the apoptosis of SGC-7901 cell induced by fuzhengxiaozheng prescription, study its antitumor mechanism in vitro. Methods: The proliferation of SGC-7901 cells was measured by MTT colorimetric assay, the apoptosis cell was analysised by flow cytometry. Results: Fuzhengxiaozheng prescription could inhibit the proliferation of SGC-7901 cells in dose-dependent manner and in time-dependent manner from 0h to 72h. The cells cultured with fuzhengxiaozheng prescription showed an apoptotic peak which was lower than that of diploid before G1 phase. The typical apoptosis morphology and hypodiploid changes of SGC-7901 were examined by electron microscopy. Conclusion: Fuzhengxiaozheng prescription can inhibit the growth of SGC-7901 in vitro,inhibiting its proliferation and inducing its apoptosis maybe one of its antitumor mechanism. KMBWM

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Available abstract

Objective: To investigate the apoptosis of SGC-7901 cell induced by fuzhengxiaozheng prescription, study its antitumor mechanism in vitro. Methods: The proliferation of SGC-7901 cells was measured by MTT colorimetric assay, the apoptosis cell was analysised by flow cytometry. Results: Fuzhengxiaozheng prescription could inhibit the proliferation of SGC-7901 cells in dose-dependent manner and in time-dependent manner from 0h to 72h. The cells cultured with fuzhengxiaozheng prescription showed an apoptotic peak which was lower than that of diploid before G1 phase. The typical apoptosis morphology and hypodiploid changes of SGC-7901 were examined by electron microscopy. Conclusion: Fuzhengxiaozheng prescription can inhibit the growth of SGC-7901 in vitro,inhibiting its proliferation and inducing its apoptosis maybe one of its antitumor mechanism. KMBWM

Key concepts: Apoptosis, Flow cytometry, In vitro, Cell growth, MTT assay, Cell, Chemistry, Molecular biology

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EXPERIMENTAL STUDY ON APOPTOSIS OF HUMAN GASTRIC CARCINOMA CELLS INDUCED BY FUZHENGXIAOZHENG PRESCRIPTION — Research Paper | ScholarLens