A comparison of effect of fluconazole and itraconazole in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.

Aim To compare the effects of fluconazole and itraconazole in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.Mthods There 115 cases were divided into fluconazole group consisted of 60 patients treated with fluconazole and and itraconazole group consited of 55 patients treated with itraconazole after allogeneic hematopoietic stem cell transplantation.The occurrence and prognosis of invasive fungal infection between the two groups were compared.Results The incidence rates of invasive fungal infection in fluconazole group and itraconazole group were 8.3% and 5.5%.without significant difference(P=0.719).Conclusions The effect of fluconazole and itraconazole is similar in preventing early invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.