Detection and evaluation of antibiotic susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in Shenzhen area

Objective To investigate the infections in urogenital tract and changing trend of drug susceptibility of mycoplasma in Shenzhen area. Methods U.ruealyticum(Uu)and M. hominis(Mh)were detected in 8,460 cases with urogenital tract infection,and the susceptibility of clinical strains to antibiotics were determined using Mycoplasma IST kit. Results 2,067 of cases were infected by U.urealyticum,54 cases were infected by M.hominis and 678 cases were positive with both species. 27.2% male were positive and 40.2% of female were positive.Only 36.1% of U u strains were susceptive to ofloxacin. 9.3% and 48.1% of Mh strains were susceptive to erythromycin and tetracycline,respectively. Pristinamycin and josamycin were the most active agents against both species. Conclusion Mixed infection and increasing resistance of mycoplasmas is a serious problem. Multiple resistance to two or more antibiotics were frequent. In view of the susceptibility of M.hominis and U.urealyticum strains to josamycin,it was still the first candidate drug against Uu and Mh. This finding also indicated that resistance monitoring of mycoplasma periodically has important significance in clinical practices.