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Expression of external-signal regulated kinase and TGF-β1 protein in human cervical carcinoma and its clinical significance

Wen Chen

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Abstract

Objective:To investigate the expression of transfer growth factor-β1(TGF-β1) in human cervical carcinoma and its clinical significance.Methods:The expression of TGF-β1 protein was detected by immunohistochemical technique in 50 cases of cervical carcinoma,25 cases of cervical intraepithelial neoplasia(CIN) and 25 cases of normal cervices.Results:The positive rate of TGF-β1 was 86%,44%,12% in cervical carcinoma,CIN and normal cervical epithelium.There was significant differences between cervical carcinoma and CIN or normal cervical epithelium in TGF-β1(P0.01).Also,there were significant differences between CIN and normal cervical epithelium in ERK and TGF-β1(P0.05).Conclusion:TGF-β1 is involved in the pathogenesis of cervical carcinoma,which may provide potent target for treatment of cervical carcinoma.

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Objective:To investigate the expression of transfer growth factor-β1(TGF-β1) in human cervical carcinoma and its clinical significance.Methods:The expression of TGF-β1 protein was detected by immunohistochemical technique in 50 cases of cervical carcinoma,25 cases of cervical intraepithelial neoplasia(CIN) and 25 cases of normal cervices.Results:The positive rate of TGF-β1 was 86%,44%,12% in cervical carcinoma,CIN and normal cervical epithelium.There was significant differences between cervical carcinoma and CIN or normal cervical epithelium in TGF-β1(P0.01).Also,there were significant differences between CIN and normal cervical epithelium in ERK and TGF-β1(P0.05).Conclusion:TGF-β1 is involved in the pathogenesis of cervical carcinoma,which may provide potent target for treatment of cervical carcinoma.

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Available abstract

Objective:To investigate the expression of transfer growth factor-β1(TGF-β1) in human cervical carcinoma and its clinical significance.Methods:The expression of TGF-β1 protein was detected by immunohistochemical technique in 50 cases of cervical carcinoma,25 cases of cervical intraepithelial neoplasia(CIN) and 25 cases of normal cervices.Results:The positive rate of TGF-β1 was 86%,44%,12% in cervical carcinoma,CIN and normal cervical epithelium.There was significant differences between cervical carcinoma and CIN or normal cervical epithelium in TGF-β1(P0.01).Also,there were significant differences between CIN and normal cervical epithelium in ERK and TGF-β1(P0.05).Conclusion:TGF-β1 is involved in the pathogenesis of cervical carcinoma,which may provide potent target for treatment of cervical carcinoma.

Key concepts: Medicine, Cervical intraepithelial neoplasia, Cervical carcinoma, Immunohistochemistry, Epithelium, Pathogenesis, Carcinoma, Transforming growth factor

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Expression of external-signal regulated kinase and TGF-β1 protein in human cervical carcinoma and its clinical significance — Research Paper | ScholarLens