Clinical Curative Efect of L-carnitine on Patients with Unstable Angina Pectoris and Influence on Serum GSH-Px,MDA

Objective To observe the clinical curative effect of L-carnitine on patients with unstable angina pectoris(UAP),and the influence on serum glutathione peroxidase(GSH-Px) and malondialdehyde(MDA).Methods 60 patients with UAP who were confirmed by coronary angiography were randomly divided into control group(26 cases) and L-carnitine group(34 cases).The control group was treated with routine therapy,the L-carnitine group received L-carnitine(3g/d) besides routine therapy.The treatment of each group lasted for 2 weeks.The clinic curative effect was observed and the serum levels of GSH-Px、MDA were detected before and after the treatment respectively.Results The total clinical curative effect rate of the L-carnitine group was higher than in the control group,the difference between the two groups was statistically significant(P0.05).After treatment,the level of GSH-Px was significantly lower in both groups than before(P0.05),and the decrement in the treatment group was more significant than in the control group(P0.05).After treatment,the level of MDA was significantly higher in both groups than before(P0.05),and the increment in the treatment group was more significant than in the control group(P0.05).Conclusion L-carnitine could significantly improve the symptom of unstable angina pectoris,L-carnitine increase the serum level of GPx while decrease the MDA.