Preparation and Optimization of Technology Parameters of Chitosan Magnetic Microspheres

Chitosan magnetic microspheres were prepared by means of suspension cross-link process.The influence of preparation parameters on the properties were analysized,including the kind and dosage of the cross-linker,pH value of the reaction medium,the Fe3O4/chitosan ratio and the agitation rate.The result shows that,the glutaraldehyde has greater cross-link strength,and is better than formaldehyde as a cross-linker;the optimal pH of the reaction medium is 4.4-6.7;the optimal ratio of Fe3O4/chitosan is 1:1.The prepared chitosan magnetic microspheres have small size,narrow distribution of diameter and sphere shape when the agitation rate is1400-1600r/min.