The Carriers of Radionuclides in Therapy--Preparation Study of Magnetic Chitosan Microspheres

In this paper, magnetic chitosan microspheres which can load radionuclides were prepared by the suspension cross-linking technique (size distribution 40μm±20μm). The magnetic material (i. e. Fe3O4) loaded in the preparation of the magnetic chitosan microspheres was prepared by coprecipitation from solution of FeSO4 and FeCl3 in basic medium. The size, size distribution and morphology of the chitosan microspheres were studied by means of SEM, IR and MASTERSIZE. The best experiment conditions were demonstrated as following: the concentration of chitosan solution at 1.5%, Fe3Q4/chitosan ratio at 1 : 2, stirring rate of the suspension medium at 1200r/min-1. The size of chitosan microspheres prepared under these conditions were about 40μm±20μm, and the morphology was all sphericity. The above results of magnetic chitosan micropheres were fitted for the basic request for the carriers of radionuclides.