A comparative study of Aripiprazole and Olanzapine in the treatment of elderly patients with Schizophrenia

Objective:To study the efficacy and safe of aripiprazole and olanzapine in the treatment of the elderly patients with schizophrenia.Methods:Seventy-one elderly patients with schizophrenia were recruited in the present study,with 36 treated with Aripiprazole(12.18±2.56)mg per day and 35 with Olanzapine(13.07±3.71)mg per day;And the therapy persisted 8 weeks.The Positive and Negative symptom scale(PANSS)and Emergent symptoms scale(TESS) were used to measure therapeutic efficacy and side effects before and at the end of 1.2.4.8 weeks of treatment respectively.Results:(1)The rate of improvement was similar between Aripiprazole group and Olanzapine group(86.1% VS 91.4%,P0.05).(2)The PANSS scores in two groups were significantly decreased from the first weekend to the eighth weekend after treatment and before treatment(P0.01).(3)The decrease radio of PANSS score between two groups had no significant difference at any time point from the first weekend after treatment(P0.05).(4)TESS showed that the adverse drug reaction in two groups were different,the overall incidence of adverse reactions State Aripiprazole group had be lower than the Olanzapine group,but no significant difference(x2=0.063,P0.05).Conclusions: State of Olanzapine and Aripiprazole on curative effect of senile schizophrenia are safe and effective,but a combination of adverse reactions to different,we should be carried out according to the principle of individual choice in the course of treatment.