Correlation between serum high-sensitive C-reactive protein level and acute ischemic stroke

Objective To study the correlation between serum high-sensitive C-reactive protein level and acute ischemic stroke.Methods Serum high-sensitive C-reactive protein level was determined in 100 patients(group A)who had onset of ischemic stroke symptoms within 72 h(including three subgroups:48 cases of cerebral thrombogenesis,24 cases of cerebral embolism and 28 cases of lacunar infarction),and in 80 healthy volunteers as normal control(group B).hs-CRP differences in the two groups and the three ischemic stroke subgroups were analyzed.Neurological functional outcomes were evaluated both in the acute phase and at the 1-month follow-up in group A by NIHSS,and the difference in NIHSS was analyzed within the three subgroups.The correlation between hs-CRP and risk factors for cerebrovascular disease was also analyzed.Results(1)Patients with acute ischemic stroke had a significantly higher level of hs-CRP than that of the healthy subjects(P0.0001).The difference between the three subgroups was also significant in the acute phase(P0.0001).But the difference between the embolism group and the lacunar infarction group was significant only at 1-month follow-up(P=0.028);(2)Hs-CRP level was significantly correlated with certain risk factors for cerebrovascular accidents,including blood glucose,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,systemic blood pressure,and D-dimer(P0.0001).Conclusions High hs-CRP level is correlated with the development and progression of acute ischemic stroke,and closely correlated with systemic blood pressure,blood glucose,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol and D-dimer.