Detection of T lymphocyte subsets,NK cells in peripheral blood of patients with acute leukemia and its clinical significances

Objective: To study the changes of T lymphocyte subsets,NK cells in peripheral blood of patients with acute leukemia and its clinical significance.Methods: The different level of peripheral blood T lymphocyte subsets,NK cells of 32 acute leukemia patients and 18 normal controls were detected with flow cytometry. Results: Compared with the normal controls,the number of CD3+ T cell,CD4+T cell,NK cell and CD4+/CD8+ ratio reduced in newly diagnosed acute leukemia group(P0.05),while those of CD8+ T cell slightly increased(P0.05).Twelve of 32 patients achieved complete remission after chemotherapy.Their level of T lymphocyte subsets,NK cells near those of normal controls(P0.05).The number of CD3+ T cell and CD4+/CD8+ ratio in newly diagnosed acute lymphoblastic leukemia group were lower than those in newly diagnosed acute myelogenous leukemia group(P0.05). Conclusion: Cellular immune function is significantly abnormal in patients with acute leukemia.Compared with acute myelogenous leukemia,patients with acute lymphoblastic leukemia had more poor cellular immune function.Detection of T lymphocyte subsets,NK cells are clinically value on evaluation of therapeutic effect and prognosis of acute leukemia.