The analysis of plasma exchange on 15 cases with acute fatty liver of pregnancy

Objective To conclude the effect and adverse events of plasma exchange(PE) on acute fatty liver of pregnancy(AFLP).Methods 15 patients with AFLP were treated with PE.Liver,renal and coagulating functions were monitored before and after treatment.Adverse events were recorded at the same time.Results After PE,clinical presentations were improved significantly.Edema was disappeared,psychosis and appetite became better.Creatinine(Cr),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),prothrombin time(PT),activated partial thromboplastin time(APTT),white blood cell count(WBC) and blood ammonia average were dcreased,serum albumin(ALB),fiber fibrinogen(Fg) level were increased,the differences were statistically significant(P0.05 and P0.01).However,plasma exchange,blood urea nitrogen(BUN),platelet count(PLT)showed no significant difference(P0.05).Conclusion PE can be used effectively and safely in treating AFLP.