2006•Unpublished venueRequires access
Effect of Different Ratio of Huangqi Decoction on Cholestatic Cirrhosis in Rats
Ping Liu, Tcm Shanghai
Open publisher page 1 citations
Abstract
Objective:To investigate the effect of different ratio of Huangqi Decoction(3∶1,6∶1,9∶1) on cholestatic cirrhosis in rats.Method:Rat cholestatic cirrhosis was duplicated by ligation of bile duct.After 1 week rats were divided into model control group and different ration of Huangqi Decoction groups.The oral administration of Huangqi Decoction lasted for 4 weeks,and then rats were sacrificed for determination of liver function,liver tissue Hyp conten and histological changes.Results:cholestatic cirrhosis was successfully duplicated after 5 weeks modeling.Compared with that of normal group,serum GGT and ALP activity,serum TBiL content and liver tissue Hyp content in model group increased significantlly(P0.05～0.01 vs sham),while serum TP and Alb content decreased significantly.Compared with that of model group,degree of cirrhosis in groups of ratio 3∶1 and 6∶1 of Huangqi Decoction alleviated significantly,serum ALP and GGT activity,serum TBiL content and liver tissue Hyp content decreased significantly(P0.05～0.01 vs 5W model).Conclusion:The ratio of 3∶1 and 6∶1 of Huangqi Decoction inhibits formation of cholestatic cirrhosis effectively.