Investigation of effective recipe based pathomechanism:effect of different recipes against cholestatic cirrhosis

Aims:To investigate action of different recipes against cholestatic cirrhosis in rats and verify the pathomechanism of this model basing on effective recipe's action.Method:Rat cholestatic cirrhosis was duplicated by ligation of bile duct.1 week after modeling,rats were divided into model control group and recipes treated groups.Rats in recipes treated groups were given Xiayuxue Decoction,Huangqi Decoction and Yiguanjian Decoction respectively for 4 weeks,and then rats were sacrificed for determination of liver function,liver tissue Hyp conten and histological changes.Results:Cholestatic cirrhosis was successfully duplicated after 5 weeks modeling.Compared with that of normal group,serum GGT and ALP activity,serum TBiL content and liver tissue Hyp content in model group increased significantlly(P0.05-0.01vs sham),while serum TP and Alb contend decreased significantly.Compared with that of model group,degree of cirrhosis in Huangqi Decoction group and Yinchenhao Decoction group alleviated significantly,serum ALP and GGT activity,serum TBiL content and liver tissue Hyp content decreased significantly(P0.05-0.01 vs sham).Conclusion:Huangqi Decoction and Yinchenhao Decoction effectively inhibits progress of cholestatic cirrhosis in rats.