2009•Practical Journal of Cardiac Cerebral Pneumal and Vascular DiseaseRequires access
Study on Combining Lactobacilli Strain with Clostridium Butyricum Strain on Mice Experimental Ulcerative Colitis
Yang Wei-fen
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Abstract
Objective Aim To investigate the therapeutic effect of combination of lactobacilli strain with clostridium butyricum strain on experimental ulcerative colitis.Methods To observed the effects of lactobacilli strain with clostridium butyricum strain,the mice ulcerative colitis was induced by Dextran sulfate Sodium(DSS) and tissue biochemical indexes and the expression of EMAP-Ⅱ in the colonic mucosa were detected.Results Lactobacilli strain and clostridium butyricum strain significantly abbreviated the damage of colonic tissue and suppressed the expression of EMAP-Ⅱ.moreover,there were the lightest histological damage and the lowest expression of EMAP-Ⅱ in lactobacilli strain combined with clostridium butyricum strain.Conclusion Both lactobacilli strain and clostridium butyricum strain show therapeutic effect on DSS induced mice ulcerative colitis.The coeffects on ulcerative colitis were observed in combination of lactobacilli strain with clostridium butyricum strain.There are lower expression of EMAP-Ⅱ in the combination group than that in the two strain group alone,which may be the molecule mechanism of the effect on mice UC partly.