2007•Chinese Journal of Disease Control and PreventionRequires access

The anti-respiratory syncytial virus effect of an active compound RG2-1 from Radix Gentianae in vitro

Zhang Jian-ju

Abstract

Objective To observe the anti-respiratory syncytial virus(RSV)effect of an active compound RG2-1 from Radix Gentianae in vitro.Methods RG2-1 was extracted from Radix Gentianae by hot water extraction,dichloromethane extract and centrifugalization.The CPE inhibition assay was used to test the antiviral activity of RG2-1 on RSV in Hela cells while ribavirin was used as a positive control.Results RG2-1 was effective antiviral agent for RSV in a concentration-dependent manner.The median toxic concentration(TC50)was 10.66 mg/ml,the median effective eoncentration(EC50)was 0.42 mg/ml and the treatment index(TI)was 25.38.Conclusions RG2-1 has an obvious anti-RSV effect in vitro.

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Key concepts: Ribavirin, Radix (gastropod), In vitro, HeLa, EC50, Chemistry, Dichloromethane, Pharmacology