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[Action of an active compound RG2-1 from radix gentianae on antirespiratory syncytial virus in vitro].

Xin Li, Xiujing Yang, Wenjing Tian, Hongyuan Li

Abstract

OBJECTIVE: To observe an action of an active compound RG2-1 from Radix Gentianae on the antirespiratory syncytial virus(RSV) in vitro. METHODS: RG2-1 from Radix Gentianae was extracted by hot water extraction and ethanol precipitation. The cytotoxic and antiviral activity of RG2-1 were tested by MTT and the CPE inhibition assay, while ribavirin was used as a positive control. RESULTS: The median toxic concentrations (TC50) of RG2-1 were 11.07 mg/ml. The direct inactivating effect, inhibition of endogenous multiplication and preventive effect of RG2-1 against RSV were observed. And the median effective concentrations (EC50) of three effects were 0.43, 0.42 and 0.48 mg/ml, respectively. The treatment indexes (TI) were 25.7, 26.36 and 23.06, respectively. CONCLUSION: RG2-1 could have significant anti-RSV effect in vitro.

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Key concepts: In vitro, Radix (gastropod), Ribavirin, Chemistry, Pharmacology, EC50, MTT assay, Traditional medicine