Analysis of Resistance of 186 Strains of Pseudomonas Aeruginosa to Antibiotics

Objective: To study the current situation and drug resistance of nosocomial infection caused by Pseudomonas aeruginosa, and to provide reference for clinical rational drug use. Methods: referring to the U.S. Committee for Clinical Laboratory Standards (NCCLS) recommended method. Using 1999 standard of NCCLS uniformly to determine the drug sensitivity, and to get the statistics of drug resistant rates by WHONET-4 Software. To analyze the drug resistence of 186 cases of clinical isolated pseudomonas aeruginosa from 2005 to 2008. Results: Pseudomonas aeruginosa infection mainly occurred in the intensive care unit(27.42%) and respiration outpatient service (24.19%); Mainly infection site is respiratory tract(58.60%, 109/186) and wound (30.06%, 57/186). the resistance rate of Pseudomonas aeruginosa to imipenem, piperacillin / tazobactam and ceftazidime is less than 14%. Conclusion: The susceptible population of Pseudomonas aeruginosa infection is critically ill patients; a mild clinical infection may choose AMK, ATM, CFP and other antibacterial drugs which changes in rates of lower resistance. We should strengthen the drug resistance testing and durg sensitivity analysis clinically