2007•Journal of Clinical UrologyRequires access
Expression and clinical significance of E2F-1 and E2F-3 in bladder carcinoma
Zhangqun Ye
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Abstract
Objective:To study the expression and clinical significance of E2F-1 and E2F-3 in bladder carcinoma.Methods:Immunohistochemistry staining was used to detect the expression of E2F-1 and E2F-3 in 39 cases of bladder carcinoma and 12 normal bladder tissues.Statistics was used to analyze the data.Results:The positive expression rate of E2F-1 in cancer tissues was 82.1%(32/39), which was significantly higher than 41.7%(5/12) in normal bladder tissue (P0.05). The expression of E2F-1 in carcinoma tissues was not correlated with tumor grade, stage and recurrence (P0.05). The positive expression rate of E2F-3 in cancer tissues was 53.8%(21/39), which was significantly lower than 91.7%(11/12) in normal bladder tissue (P0.05). The expression of E2F-3 was closely associated with tumor grade and stage (p0.05).Conclusions:Aberrant expression of E2F may play an important role in development and progression of bladder carcinoma, and can be used in predicting tumor malignancy.