Expression Survivinin Bladder Carcinoma and its Clinical Implications

Objective To study the expression of apoptosis inhibitor gene Survivinin the bladder carcinoma tissues and its clinical implications.Methods We detected the expression of Survivinin the tissues from 60 patients with bladder transitional cell carcinoma and analyzed the relationship between it’s expression and the clinicopathological characteristics.Results The positive rate of Survivinin the bladder carcinoma tissues from 60 patients was 65.00%.No Survivinwas expressed in the normal bladder tissues from 10 healthy controls.The positive rates of Survivinin gradeⅠ,Ⅱand Ⅲ bladder carcinoma were 37.50%,68.96% and 86.66%,respectively.The positive rate of Survivinin grade I was significantly lower than that in grade Ⅱand Ⅲ(P0.05).The positive rate of Survivinin T1,T2 and T3 was 54.54%,70.00% and 85.71%,respectively,which showed a trend of increased expression of Survivinwith more advanced stages,but there was no statistically significant difference among them (P0.05).The positive rate was 75.00% in the tissues from patients with recurrent disease.Conclusion Survivinmay play an essential role in the carcinogenesis and development of bladder carcinoma.Detection of the expression of Survivinin the tissues from bladder carcinoma may be helpful in evaluating the prognosis of the patients.It may also be used as one of the markers in monitoring the relapse.