Determination and analysis of plasma brain natriuretic peptide in patients with diastolic heart failure and high sensitivity C reactive protein

Objective To discuss and evaluate the correlation of high sensitive C reactive protein(hs-CRP) and brain natriuretic peptide(BNP) and diastolic heart failure.Methods BNP and hs-CRP levels of 50 patients with heart failure patients before and after treatment were measured respectively,and compared with 50 healthy persons.Results Plasma hs-CRP and BNP levels in the observation group were higher than those in the control group with significant difference(P 0.01);plasma BNP and hs-CRP levels in NYHA class Ⅳ patients were higr than those in Class Ⅲ patients with significant difference(P 0.01).Plasma hs-CRP and BNP level in observation group with the cardiac function of Ⅰ-Ⅱ level decreased compared with before treatment,differences were significant(P 0.01).The serum BNP levels of patient in observation group had positively correlation with hs-CRP.Conclusion The levels of plasma hs-CRP and BNP increase when heart failure occurs,they increase with the degree of cardiac function damages,while they decrease significantly after treatment,which indicates that the levels of plasma hs-CRP and BNP can reflect the changes degree of heart failure disease.