2006•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Influence of Genistein on Uterine Endometrial Cancer Cell Line,Ishikawa

Li Zhou

Abstract

BACKGROUND AIM: To determine the influence of 4,5,7- triatomic isoflavone (genistein)on uterine endometrial cancer cells. MATERIALS AND METHODS: Uterine endometrial cancer cells (ishikawa) were cultured in vitro with different genistein concentrations, and the influence of genistein on cell proliferation and growth inhibition was detemined by 5-bromo-2'-deoxyuridine incorporation assay (BrdU). RESULTS: The concentration of genistein at 12.5～25 μmol/L could significantly enhance cell proliferation.The concentration of genistein at 100 μmol/L significantly inhibited cell proliferation. CONCLUSION: The proliferating or inhibitiory effects of genistein on endometrial cancer cells vary with genistein concentrations.

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Key concepts: Genistein, Endometrial cancer, Cell growth, Chemistry, Internal medicine, In vitro, Cell culture, Endocrinology