Protective Effect of Jiangzhi Ninggan Capsule on Acute Hepatic Injury Induced by D-Galactosamine in Mice

Objective To observe the effect of Jiangzhi Ninggan capsule on acute hepatic injury induced by D-galactosamine(D-Gal) in mice.Methods Sixty mice were divided into six groups at random: model group,control group,Bifendate group(positive control group),Jiangzhi Ninggan Capsule groups(high dose,middle dose,low dose).The mice in treatment groups were administered medicine respectively via gavage,while the others in control and model groups were treated with the same dose of nomal saline.After six days,all of the mice except those in the control group were treated with intraperitoneal injection of 10% D-Gal(1 000 mg/kg).twenty-four hour later,the mice were killed and the blood sample and liver tissue were taken.Liver pathological changes were observed and the activities of serum ALT,AST,and the content of liver MDA were detected.Results Compared with the model group,the effect on levels of ALT,AST in blood and the content of MDA in liver tissue of Jiangzhi Ninggan Capsule groups(high dose、middle dose) were reduced significantly(respectively,P0.05;P0.01;P0.001),and the liver pathological changes were lightened obviously in dose.Conclusion Jiangzhi Ninggan capsule has protective acute hepatic injury induced by D-galactosamine.