Study for the clinical value of serum cancer antigen 125 in the diagnosis of malignant tumor

Objective: To explore the clinical value of serum CA125 for diagnosis in ten kinds of malignant tumors. Methods: Technique of electro-chemiluminescence was used to measure the serum CA125 of un-treated 717 patients with malignant tumors and 50 normal controls. Results: Positive expression rates of CA125 in 47 liver cancer, 97 ovarian cancer, 92 lung cancer, 27 malignant lymphoma, 42 stomach cancer, 13 nasopharyngeai cancer, 180 cervical cancer, 67 breast cancer, 32 thyroid cancer, 120 esophagus cancer were 57.57%, 36.08%, 31.52%, 29.63%, 23.80%, 23.07%, 21.11%, 13.43%, 12.50%, 10.83% respectively. There were significantly differences (P0.05) in comparing liver cancer group, ovarian cancer group, stomach cancer group with nomal control group. Conclusion: Preoperative serum CA125 level may have the referential value of clinical diagnosis in liver cancer, ovarian cancer and stomach cancer. Serum CA125 level of preoperation might be helpful for monitoring illness stage, especially for the patients who had abnomaL CA125 level before operation.