Effect of Yaotui Litongsan on Nerve-related Behavior of Autograft of Nucleus Pulposus to Cavum Epidurale in Rats

Objective To observe effect of Yaotui Litongsan on nerve-related behavior of autograft of nucleus pulposus to cavum epidurale in rats.Methods Fifty normal Wistar rats were randomly divided into five geoups:the sham operated group (A),injury model group (B),Yaotongning treat group (C),high dose and low dose group (Yaotui Litongsan treat,D and E),10 rats in each group.Autogenous nucleus pulposus was removed from the coccygeal vertebral and placed into the back of L5～6 nerve roots of left cavum epidurale,making the non-compressive model with transplanted autogenous nucleus pulposus.The mechanical withdraw threshold and thermal withdraw latency were determined.Results The significant mechanical hyperalgesia was showed in the rats of B,C,D,E groups postoperatively,but it was lighter in C,D,E groups than in B group (P0.05),and it was lighter in D,E groups than in C group (P0.05).All groups didn’t show thermal hyperalgesia.Conclusion Yaotui Litongsan can lighten the mechanical hyperalgesia caused by non-compressive nucleus pulposus and heighten pain threshold.