Effect of Duzhongyaotong pill(杜仲腰痛丸) on histologic changes of nerve root injury induced by the non-compressive nucleus pulposus protrusion in rat

Objective: To observe the effect of duzhongyaotong pill(杜仲腰痛丸) on histologic changes of nerve root injury induced by the non-compressive nucleus pulposus protrusion in rat.Methods: Fifty normal Wistar male rats were randomly divided into five groups:the sham operation group(A),model group(B),shenjindan capsule(伸筋丹胶囊) group(C),high dose and low dose group of duzhongyaotong pill(D and E) with 10 rats in each group.Autogenous nucleus pulposus was removed from the coccygeal vertebrae and placed into the back of left L_5,L_6 nerve root,thus the modle of the non-compressive nucleus pulposus protrusion was made.After 2 weeks,the histologic changes of nerve root of the rats were observed.Results: There were significant difference on histologic changes of nerve roots in the group B,C,D,E,but it is lighter in group C,D,E than group B.Conclusion: Duzhongyaotong pill can lighten histologic changes of nerve root induced by the non-compressive nucleus pulposus protrusion,ameliorate or restrain inflammation reaction,which can protect nerve root.