Effect of Duzhongyaotong pill on the non-compressive nucleus pulposus protrusion in the rat’s pain-related behavior

Objective To observe effect of duzhongyaotong pill on the non-compressive nucleus pulposus protrusion in the rat’s pain-related behavior.Methods Fifty normal Wistar male rats were randomly divided into five geoups:the sham operated group(A),injury model group(B),shenjindan capsule treat group(C),high dose and low dose group(duzhongyaotong pill treat,D and E)(n=10 each).Autogenous nucleus pulposus was removed from the coccygeal vertebral and placed into the back of left L(5~6) nerve root,The modle of the non-compressive nucleus pulposus protrusion was created by transplanting autogenous nucleus pulposus in the back of left L(5~6) nerve roots.The mechanical withdraw threshold and thermal withdraw latency were determined.Results The significant mechanical hyperalgesia was showed in the rats of B,C,D,E groups,but it’s lighter in C,D,E groups than in B group postoperatively (P0.05),and it’s lighter in D,E groups than in C group postoperatively (P0.05),all groups didn’t showed thermal hyperalgesia.Conclusion Duzhonhyaotong pill can lighten that the non-compressive nucleus pulposus protrusion cause mechanical hyperalgesia and heighten pain threshold.