Calcitriol Improving Microinflammation and Oxidative Stress in Patients with Maintenance Hemodialysis

Objective To investigate the effect of Calcitriol on microinflammation and oxidative stress in maintenance hemodialysis(MHD)patients.Methods Sixty stable MHD patients were divided randomly into groups therapy and control,30 in each.Control group were given conventional drug treatment;Therapy group were given,based on conventional,additional calcitriol soft capsules,orally,0.50 μg/d.The course lasted 12 weeks,and the both groups didn′t use angiotensin converting enzyme inhibitor(ACEI),angiotensin II receptor antagonist or statins.Another 30 healthy subjects enrolled as normal group.Serum levels of high-sensitivity C-reactive protein(hs-CRP),interleukin 6(IL-6),TNF-α and plasma malonaldehyde(MDA),glutathione peroxidase(GSH-PX) were observed.Results Before treatment,there was significant difference in hs-CRP,IL-6,TNF-α,MDA,GSH-X between 3 groups(P0.05).As compared with normal group,the levels of hs-CRP,IL-6,TNF-α,MDA increased,GSH-PX decreased,the difference was significant(P0.05).After 12 weeks of calcitriol treatment,there was difference in hs-CRP,IL-6,TNF-α,MDA,GSH-X between 3 groups(P0.05).As compared with pre-treatment and control group after treatment,hs-CRP,IL-6,TNF-α,MDA decreased,GSH-X increased in therapy group,the difference was significant(P0.05).There was not difference in hs-CRP,IL-6,TNF-α,MDA,GSH-X between pre-and 12-week treatments in control group(P0.05).Conclusion Microinflammation and oxidative stress,existing in MHD patients,can be improved obviously by calcitriol.