Effects of lycopene on microinflammatory and oxidative stress in old age maintenance hemodialysis patients

OBJECTIVE To observe effects of lycopene on microinflammatory and oxidative stress in great age maintenance hemodialysis patients(MHD).METHODS 30 MHD patients were randomly divided into two groups: blank group(n=15) and treatment group(n=15).In treatment group,the patients were given lycopene,2# oral,twice a day for eight weeks.Their serum ferritin(SF),IL-1β,IL-6,IL-10,TNF-α,MDA,GSH-Px,SOD,Alb and CRP were measured at pre-and post-treatment.RESULTS Compared with the pre-treatment,the levels of serum IL-1β,IL-6,IL-10,TNF-α,MDA,GSH-Px,SOD,and CRP in both groups elevated markedly(P0.01 or 0.05).but the diference value of serum IL-1β,IL-6,IL-10,TNF-α,CRP and SOD in treatment group was more than those in blank group(P0.05).CONCLUSION There are mircoinflammation and oxidative stress in great age MHD patients,which could be alleviated by lycopene.