Comparative study of Aripiprazole and Risperidone in the treatment of schizophrenia

Objective: To compare the efficacy and adverse reactions of Aripiprazole and Risperidone in the treatment of schizophrenia. Methods: 95 patients with schizophrenia were randomly divided into two groups,were given Aripiprazole or Risperidonefor treatment of 12 weeks. The Positive and Negative Syndrome Scale( PANSS) and the Treatment Emergent Side Effect Scale( TESS) were used to assess the clinical efficacy and the adverse reaction respectively before and after the treatment. Results: The total efficiency rates and the clinical cure rate in the Aripiprazole group were 79. 74% and 56. 67% respectively,obviously higher than those in the Risperidone group( 61. 05% and 29. 47%),two groups of PANSS score were significantly decreased after treatment( P 0. 01),in the treatment,the reduction rate and adverse reaction of the Aripiprazole group were obviously higher than the Risperidone group( P 0. 05). Conclusion: In the treatment of schizophrenia,the total efficiency rates and the clinical cure rate of Aripiprazole were better than Risperidone,and has low adverse reactions and good compliance.