Parecoxib preemptive analgesia effect and influence on BG,CRP and IL-6

Objective To investigate analgesia effect of parecoxib preemptive analgesia and its influence on related inflammatory factors.Methods 80 patients undergoing elective spine surgery patients were randomly divided into observation group and control group,with 40 cases in each group,observation group during anesthesia induction to Parecoxib 40mg intravenous drip,and the control group after intravenous drip Parecoxib 40 mg,regular line given fentanyl self-control intravenous analgesia(PCIA),compare the anesthesia(T0) and finish before(T1),6 h after surgery(T2),12 h after surgery(T3) in patients' blood glucose(BG),C-reactive protein(CRP),interleukin-6(IL-6) concentrations at different time after operation the pain(VAS) score.Results Operation time was(136.88 ± 52.48) min,observation group patients in the control group was(130.13 ± 67.41) min,there was no statistically significant difference(P 0.05);postoperative 4h,12 h,24 h VAS score in observation group were obviously lower than those of control group(P 0.05).Conclusion Parecoxib used for spinal surgery patients analgesia can significantly relieve postoperative pain degree,it was conducive to inhibit the surgical stress response.