Clinical Observation on Preemptive Analgesia Effects of Parecoxib for Patients with Colorectal Carcinoma Surgery

Objective To investigate the preemptive analgesia effect of parecoxib for patients with colorectal carcinoma surgery.Methods 42 patients undergoing colorectal carcinoma surgery under total intravenous anesthesia were randomly divided into two group: the parecoxib group(gorup P,n = 21) were intravenous injected parecoxib sodium at 10 minutes before operation and the control group(gorup C,n = 21) were intravenous injected 2 ml physiological saline.Patient controlled intravenous analgesia(PCIA) was used after operation in both groups.Visual analog scale(VAS) and adverse reaction at 2,6,12,24 hours were recorded after operation.Results VAS score in group P observed at 2,6,12 hours time point significantly less than that of in group C(P 0.05).Adverse reaction of the medication was no significant difference in both group P and C(P 0.05).Conclusion Intravenous parecoxib sodium before operation can safely,effectively offer preemptive analgesia for patients receiving colorectal cancer surgery.