Effect of parecoxib as pre-anesthesia treatment on postoperative pain in thyroid surgery

[Objective] To observe and evaluate the effect of preemptive analgesia with parecoxib on postoperative pain in thyroid surgery.[Methods] Three hundred ASA Ⅰ or Ⅱ patients of both sexes aged 18~65 yr with body mass index 17~29 kg/m2 were randomized into two groups,parecoxib group(n=150) and normal saline group(n=150) as control.Five minutes before the induction of anesthesia,40 mg parecoxib was given in parecoxib group.VAS was used to measured pain intensity and recorded at 0,2,6,12 and 24 h after operation.Usage of pethidine,nausea,vomiting and patient′s satisfaction were monitored.[Results] Compared with control group,VAS scores were lower,the level of patient′s satisfaction was higher,and pethidine was used less in parecoxib group(4.00%,P 0.05).There was no difference in nausea and vomiting between groups.[Conclusion] Parecoxib 40 mg given before induction of anesthesia can improve preemptive analgesia.