Expression and the clinical sighificance of MMP-9, TIMP-1 and Hs-CRP in patients with acute coronary syndrome

Objective:To explore the effect of matrix-metalloproteinase-9 (MMP-9), tissue inhibi-tor of metalloproteinase-1 (TIMP-1) and high sensitive C-reactive protein (hs-CRP) on acute coronary syndrome (ACS). Methods:Fifty-three patients with acute coronary syndrome (ACS) were enrolled as ACS group, in which 28 patients with acute myocardium infarct (AMI) and 25 patients with unstable angina (UA) as well as 28 patients with stable angina (SA) were studied as SA group and 30 health volunteers served as control group. MMP-9, TIMP-1in serum were measured with ELISA, hs-CRP in serum was measured with immunoturbidimetric method. The data were analysed with SPSS software. Results: The levels of MMP-9,hs-CRP in ACS group were significantly higher than these in SA group and the control grou(pP0.01). The level of TIMP-1 in ACS group was significantly lower than that in control grou(pP0.01),and was no significantly difference between the SA grou(pP0.05). The levels of MMP-9/TIMP-1 were significantly higher than that in SA group (P0.05)and the control grou(pP0.01).MMP-9,TIMP-1 and MMP-9/TIMP-1 were significantly related with hs- CRP in ACS patients. Conclusions:Inflammation may be one of the risk factors which induces ACS.The high expression of MMP-9 and the imbalance of MMP-9 and TIMP-1 promote devision of plaques which involves in ACS. MMP-9, TIMP-1、MMP-9/TIMP-1 are associated with ACS patients closely and they can be new and important serum markers indicating ACS. To investigate serum MMP-9, TIMP-1, MMP-9/TIMP-1 and hs-CRP can be effective serum markers of the plaque destabilization and rypture.