The Role of Serum High Sensitive C-reactive Protein and Matrix Metalloproteinase-9 in Risk Stratification of Patients with Acute Coronary Syndrome

Objective To observe the change of serum high sensitive C-reactive protein(hs-CRP) and matrix metalloproteinase-9(MMP-9)in patients with acute coronary syndrome(ACS),and explore the role of hs-CRP and MMP-9 in ACS.Methods: Forty-eight patients with ACS were enrolled in experiment group,in which there were 12 patients with acute myocardial infaction(AMI) and 36 patients with unstable angina(UA).Meanwhile,12 patients without coronary heart disease were as control.The levels of hs-CRP and MMP-9 were detected and compared.Results: The levels of hs-CRP and MMP-9 in ACS group were significantly higher than that in control group(P0.01);the levels of hs-CRP and MMP-9 in AMI group were significantly higher than that in UA group(P0.01).Conclusion: The elevation of hs-CRP and MMP-9 in serum is closely associated with ACS,particularly AMI,and may serve as an indicator for predicting ACS and AMI.