To Study the Expression of p16 in Benign and Malignant Gastric Lesions

Objective To study the expression of p16 suppressor gene in benign and malignant gastric lesions and its correlation with occurrence and development of gastric cancer.Methods p16 was observed in 10 normal gastric tissue、35 benign lesions and 65 gastric cancer with LSAB immunohistochemical methods.Results The positive expression rate of p16 in the normal gastric tissue was 100%,the rate of benign lesions was 75%~87.5%,the rate of gastric cancer was 30.8%.The positive expression rate of p16 was higher in high and middle differentiation than low and small cell carcinoma (P0.05) ,The positive expression of p16 was significantly correlated with TNM stage.Conclusion p16 may play some roles in the development of gastric cancer, the expression of p16 may assess the prognosis in gastric cancer.