A control study of Aripiprazole and Aripiprazole combined with Sertraline in the treatment of obsessive-compulsive disorder

Objective:To explore the efficacy and safety of Aripiprazole and Aripiprazole combined with Sertraline in the treatment of obsessive-compulsive disorder.Methods:43 patients met the DSM-IV criteria for OCD were randomly divided into single drug group(n=21) and combined drug group(n=22),the single drug group was given Aripiprazole,combined drug group was given Aripiprazole combined with Sertraline,treatment for 12 weeks.The efficacy and side effects were assessed with Yale Brown Obsessive Compulsive Scale(Y-BOCS) and Treatment Emergent Symptom Scale(TESS) before treatment and at the 2nd,4th,8th,12th weekend.Results:The total scores of Y-BOCS decreased significantly at 4th weekend in the single drug group(P0.05).The totle scores of Y-BOCS decreased significantly at 2nd weekend in the combined drug group.The total effective rate of the single drug group was 52.4%,the total effective rate of the combined drug group was 68.1%,there were significant differences between the two groups(P0.05).Conclusion:Aripiprazole can be used alone to treat obsessive-compulsive disorder,but combined with SSRI has better efficacy.