Pharmacodynamic Studies of Huoluojiangu Capsule on Analgesic Experiments

Objective To observe effect of Huoluojiangu capsule (HJC) on analgesic experiments. Methods The 3 kinds of analgesic experiments of whirling body, electric irritation and hot board were respectively adopted in mice. 60 mice were randomly divided into 6 groups in every analgesic experiment:A group(blank control), normal saline 0.25 mL/10 g. B group (positive control), diclofenac sodium 3.5 mg/kg;C group (positive control), pethidine 15 mg/kg, D,E and F group were respectively as low,mid and high dose of HJC groups (HJC 14, 21, 28 g/kg). Afterward, effects of HJC on ache induced by chemistry, electricity and heat were respectively observed at different time after pretreatments. Results Low, mid and high dose of HJC groups can all inhibit reaction of whirling body by chemical irritation. Compared with blank control group, low dose of group had evidently effect, P 0.01. Mid and high dose of HJC groups had stronger effect (P 0.001). As for braying reaction by electric irritation, low dose of group was effective (P 0.05), and mid and high dose of HJC groups had evidently effect (P 0.01), compared with blank control group. Every group of HJC can also markedly prolong period of pain reaction by hot board compared with blank control group, P 0.05. Analgesic effect of HJC was not different from positive groups (B and C group) at 30, 60 and 120 min (P 0.05), but it had stronger analgesic effect than positive groups (B and C groups) at 180 min, P 0.05. Conclusion HJC possesses better analgesic effect, its action was slower and longer than pethidine (pouring stomach) and its potency was larger than diclofenac sodium.