Comparison between effects of insulin aspart and human insulin NOVO R via continuous subcutaneous insulin infusion pump on hyperglycemia in elderly patients with type 2 diabetes

[Objective] To compare the efficiency of insulin aspart and human regular insulin(NOVO R) via continuous subcutaneous insulin infusion(CSⅡ) pump on hyperglycemia in elderly patients with type 2 diabetes. [Methods] 55 hospitalized patients with type 2 diabetes who had poorly controlled blood glucose were randomly divided into 2 groups to undergo insulin pump therapy with aspart or NOVO R for two weeks, the changes of blood glucose(include before and after three meals and bedtime), the time and the dose of insulin needed for good glycemia control were compared between two groups, the frequency of hypoglycemia was recorded. [Result] No significant differences in blood glucose between the two groups were observed in bedtime and before three meals(P 0.05), the time for good glycemia control was shorter in the aspart group than in NOVO R group(P 0.01),postprandial blood glucose after 3 meals and the mean dose of insulin used and the frequency of hypoglycemia in the aspart group were significantly lower in the aspart group than in the NOVO R group (P 0.05). [Conclusion] Insulin aspart via CSⅡ is as efficacious as NOVO R in controlling hyperglycemia in elderly type 2 diabetes, but insulin aspart provides a more effective and faster control of postprandial hyperglycemia with less insulin used and lower frequency of hypoglycemia.