Effects of soybean polysaccharide on antitumor and immunological mechanism of mice bearing S_(180)

To study the effect of soybean polysaccharides(SSPS)on antitumor and immune regulation of mice bearing S180.The effect of SSPS on antitumor and spleen index and thymus index were observed by tumor transplant experiment of animal;MTT examines T-lymphoid cell proliferation of the mice of tumor cell with S180;Adopting flow cytometry to determine T cell faciation;Use the ELISA method to examine the serum level of IL-2 in tumor mice.SSPS can inhibit the growth of S180 and the effect of high dose group was best.The spleen index was influenced by every dose group but thymus index was inhibited by middle and high dose;it can enhance the T cell proliferation after the ConA provok and has significantly difference.SSPS can enhance the CD+4T cell number in different extent,increase the CD+4/CD+8 cell ratio;SSPS can obviously enhance the serum level of IL-2,have significantly difference.SSPS had the notable anti-tumor,increased T-lymphoid cell proliferation,and promoted IL-2 secreting thus played its anti-tumor role.