Expression of p53 Protein in Laryngeal Squamous Cell Cancinoma and its Clinical Significance

Objective To evaluate the clinic significance of the expression of p53 protein in laryngeal squamous cell cancer(LSCC).Methods p53 protein was detected by immunohistochemical method in 54 cases of LSCC,42 cases of laryngeal atypical hyperplasia(LAH) and 28 cases of laryngeal normal mucosa(LNM) in paraffin -embeded block.Results The positive expression rates of p53 protein were 53.7%,38.1% and 0 in the tissue of LSCC,LAL and LNM,respectively,showing a statistically significant difference between them(P0.05).The positive rates of p53 was also significantly different between the severe and medium to mild LAH(68.8% vs 21.4% to 16.7%) or between simple LAH and NLM surrounding the cancer(8.3% vs 0).The expression of p53 was considerably higher in the invasion margin and in the cancer nest margin than in the superficial and central part of the cancer(P0.05).The expression of p53 protein was related to differentiation and lymph node metastasis of LSCC(P0.05).Conclusion The overexpression of p53 protein may occur in the early stage of LSCC.The cells with p53 gene mutationthese in the paratumour tissue are likely the source of tumor recurrence.The p53 expression is related to the differentiation,invasion and metastasis and can be used as a valuable marker for the prognosis of LSCC.