Elevation of Interlukin-6 and C-Reactive Protein in Unstable Angina Patients

Objective This study is aimed to investigate the change of IL-6 and C-reactive protein and relation between these two in unstable angina patients.Methods One hundred patients with coronary artery disease who were documented by angiography or previous myocardial infarction were recruited, among them, 40 cases with unstable angina (the class of Braunwald Ⅲ B), 60 cases with chronic stable angina, all the patients' sera was analysed for IL-6 and CRP with enzyme-linked immunosorbent assay (ELISA).Results IL-6 and CRP were significantly elevated in unstable angina patients than in chronic stable angina patients(CRP:2.09±3.65 vs 0.92±0.94mg/L, P 0.05; IL-6:12.72±13.42pg/ml vs 6.86±2.93pg/ml, P 0.01, respectively). However, the percent change with CRP3mg/L in unstable angina group was 17.5%, and that in chronic stable angina group was 5%. Moreover, univariate regression analysis did not show significant relation between CRP and IL-6 ( r=0.031,P 0.05).Conclusion IL-6 and CRP are elevated in unstable angina group; both CRP and IL-6 can be used as markers of unstable angina, however, this study does not find significant association between CRP and IL-6.