Study on relationship between the expressions of ER,PR,HER-2/neu and the effective rate of neoadjuvant chemotherapy of breast cancer

Objective To investigate the relationship between the expressions of ER,PR and HER-2/neu with the effective rate of neoadjuvant chemotherapy for breast cancer,and investigate the predictive index on neoadjuvant chemotherapy for breast cancer. Methods Expression of ER,PR and HER-2/neu in breast cancer of 160 patients received neoadjuvant chemotherapy were detected by immunohistochemical method before and after chemotherapy. The relationships of the expression levels and the effective rate were evaluated. Results Among the 160 cases of neoadjvant chemotherapy ,the percentage of negative for ER,PR and over expression for HER-2/neu were 35.63%,24.38%,33.13% respectively. In the differences of chemotherapeutic effective rate between ER negative (-) and ER positive (+),PR negative (-) and PR positive(+),HER-2/neu over-expressed group and HER-2 non over-expressed group,there were statistical significance(χ2 3.875,P0.05).The change of ER,PR and HER-2/neu over expression after neoadjuvant chemotherapy didn't have statistical significance.Conclusion In the patients with breast cancer,ER or PR negative is more sensitive to chemotherapy. These patients may get more benefits from chemotherapy. The patients with HER-2/neu over expressed are easily resistant to chemotherapy. ER,PR and HER-2/neu can be considered as predictive markers of the effective rate of neoadjuvant chemotherapy. Neoadjuvant chemotherapy doesn't change the expression of ER,PR and HER-2/neu.