The role of relative factors on the effect of neoadjuvant chemotherapy for the patients with breast cancer

Objective Neoadjuvant chemotherapy is one of the important means for the management of breast cancer.This study was to investigate the correlation of the effectiveness of neoadjuvant chemotherapy with the expressions of ER,PR and HER-2 in the treatment of breast cancer.Methods We detected the expressions of ER,PR and HER-2 in 40 breast cancer patients receiving neoadjuvant chemotherapy by immunohistochemical methods and observed the therapeutic results.Results Among the 40 patients,the negative expressions of ER and PR were 42.5 and 52.5%,respectively,and the overexpression of HER-2 was 37.5%.Statistically significant differences were found in chemotherapeutic effectiveness between the ER positive and ER negative groups(P0.05) as well as between the PR positive and PR negative groups(P0.05),but not between the HER-2 overexpressed and HER-2 non-overexpressed groups(P0.05).Conclusion ER and PR negative patients with breast cancer are more sensitive to chemotherapy.ER and PR negative may be the predictive factors of the sensitivity of neaodjuvant chemotherapy.