Relationship between expression of ER,PR,p53,Her-2 and the effective rate of neoadjuvant chemotherapy in breast cancer

Objective To investigate the relationship between the expressions of ER, PR, p53 and Her-2 with the effective rate of neoadjuvant chemotherapy for breast cancer. Methods Expression of ER, PR, p53 and Her-2 in breast cancer of 178 patients received neoadjuvant chemotherapy were detected by immunohistochemical method before chemotherapy. Results Among the 178 cases of neoadjvant chemotherapy , the percentage of negative for ER, PR, p53 and over expression for Her-2 were 33.15%, 23.60%, 60.67%, 35.39% respectively. In the differences of chemotherapeutic effective rate between ER negative and ER positive , PR negative and PR positive, p53 negative and p53 positive, there were statistical significance (P0.05). But between Her-2 overexpressed group and Her-2 non-overexpressed group, there were not statistical significance (P0.05).Conclusion In the patients with breast cancer, ER ,PR or p53 negative are more sensitive to chemotherapy. These patients may get more benefits from chemotherapy. ER, PR and p53 can be considered as predictive markers of the effective rate of neoadjuvant chemotherapy.