Application of Anaesthesia with Reminfentanil and Propofol in Craniocerebral Operations

Objective To investigate clinical value of reminfentanil and propofol in craniocerebral operations. Methods 120 cases of patients in ASA degreeⅠ～Ⅲ,which need endotracheal anesthesia in operating,were at random divided into two groups: the reminfentanil group and the fentanyl group.Induction of anesthesia was used by intravenous injection with midazolam,vecuronium,etomidate and reminfentanil(or fentanyl),and maintenance of anesthesia was kept by pouring with reminfentanil(or fentanyl) and propofol.Changes of haemodynamics and anesthesia palinesthesia(including pain-killer usage) were observed and recorded continuously during every period of operation.Results Changes of haemodynamics shew after induction BP and HR of the two groups were both lower than the baseline.While 1 minute after intubating the data of the fentanyl group were higher than baseline,after extubating the data of the reminfentanil group were significanly higher than baseline.Anesthesia palinesthesia time were shorter in the reminfentanil group than in the fentanyl group.There were more usage of pain-killer and fewer restlessness in the reminfentanil group.Conclusion Reminfentanil could be more efficient than fentanyl in endotracheal anesthesia of craniocerebral operations,including stable efficiency,fast metabolism and profit to early extubation and analepsia.