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2008•The Journal of Clinical PsychiatryRequires access

Comparative study between mirtazapine and fluoxetine in the treatment of depression

Liyin Zhang

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Abstract

Objective:To compare the clinical efficacy and safety between mirtazapine and fluoxetine in the treatment of depression. Method:Sixty patients with depression were randomly divided into mirtazapine group and fluoxetine group for 6 weeks.Hamilton rating scale for depression(HAMD) and treatment emergent symptoms scale(TESS) were used to evaluate the efficacy and adverse effects. Results:There was a similar efficacy between the two groups,with response rate 80.0% for mirtazapine group and 76.7% for fluoxetine group.mirtazapine group showed a higher response rate compared with fluoxetine group after one week treatment. Conclusion:Mirtazapine is a safe and effective antidepressant,with rapid efficacy.

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What this paper is about

Objective:To compare the clinical efficacy and safety between mirtazapine and fluoxetine in the treatment of depression. Method:Sixty patients with depression were randomly divided into mirtazapine group and fluoxetine group for 6 weeks.Hamilton rating scale for depression(HAMD) and treatment emergent symptoms scale(TESS) were used to evaluate the efficacy and adverse effects. Results:There was a similar efficacy between the two groups,with response rate 80.0% for mirtazapine group and 76.7% for fluoxetine group.mirtazapine group showed a higher response rate compared with fluoxetine group after one week treatment. Conclusion:Mirtazapine is a safe and effective antidepressant,with rapid efficacy.

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Available abstract

Objective:To compare the clinical efficacy and safety between mirtazapine and fluoxetine in the treatment of depression. Method:Sixty patients with depression were randomly divided into mirtazapine group and fluoxetine group for 6 weeks.Hamilton rating scale for depression(HAMD) and treatment emergent symptoms scale(TESS) were used to evaluate the efficacy and adverse effects. Results:There was a similar efficacy between the two groups,with response rate 80.0% for mirtazapine group and 76.7% for fluoxetine group.mirtazapine group showed a higher response rate compared with fluoxetine group after one week treatment. Conclusion:Mirtazapine is a safe and effective antidepressant,with rapid efficacy.

Key concepts: Mirtazapine, Hamd, Fluoxetine, Antidepressant, Hamilton depression scale, Depression (economics), Rating scale, Adverse effect

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