Comparative study of Mirtazapine and Fluoxetine in the treatment of depression

Objective:To explore the efficacy and safety of Mirtazapine and Fluoxetine in the treatment of depression.Methods:70 patients with depression were randomly devided into two groups,with Mirtazapine or Fluoxetine for 8 weeks.HAMD scale and Tess scale were used to evaluate efficacy and side effects respectively before and at ends of 1,2,4,8 weeks of treatment.Results:Compare two groups′ HAMD scores before treatment and after treatment of 1,2,4,8 weeks.At the 1st weekend,the reduction of mirtazapine group was greater than fluoxetine group.There was significant different(P0.05).At the 2nd weekend,the reduction rate of fluoxetine group was greater than mirtazapine group.There was significant different(P 0.05).After treatment of 4,8 weeks,there was no statistical different in efficacy(P0.05).Two groups showed no significant difference in adverse reactions.Conclusion:In the treatment of depression,Mirtazapine and Fluoxetine are similar in efficacy.Mirtazapine is quicker in efficacy beginning and it can be used in clinical practice.